Atorvastatin 20mg walmart - Indications and Usage for Atorvastatin

Body as a whole: No cases of rhabdomyolysis were reported. Diabetes was reported as an adverse reaction in subjects 6. The incidence walmart fatal hemorrhagic stroke was similar between groups 17 Atorvastatin calcium vs.

Atorvastatin incidence of non-fatal hemorrhagic strokes was significantly greater 20mg the Atorvastatin group 38 non-fatal hemorrhagic strokes as compared to the placebo group 16 non-fatal hemorrhagic strokes, atorvastatin 20mg walmart.

There were no significant differences between the treatment groups for all-cause mortality: The proportions of subjects atorvastatin experienced cardiovascular atorvastatin were numerically smaller in the Atorvastatin calcium 80 mg group 3. The proportions of subjects who experienced non-cardiovascular death were numerically walmart in the Atorvastatin calcium 80 mg group 5. Postmarketing Experience The following adverse reactions have been identified during 20mg use of Atorvastatin calcium.

Because these reactions are reported voluntarily from a population 20mg uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse atorvastatin associated with Atorvastatin calcium therapy reported since market introduction, that are not listed above, regardless of causality assessment, include the following: There have been rare reports of immune-mediated necrotizing myopathy associated with statin use [see Warnings and Precautions 5.

There have been rare postmarketing reports of cognitive impairment e. These cognitive issues have been reported for 20mg statins. The reports are generally nonserious, atorvastatin 20mg walmart, and walmart upon statin discontinuation, with variable times to symptom 20mg 1 day to years and symptom resolution median of 3 weeks. Drug Interactions 20mg risk of walmart during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or strong CYP 3A4 inhibitors e, atorvastatin 20mg walmart.

Concomitant administration of Atorvastatin calcium with strong inhibitors of CYP walmart can lead to increases in plasma concentrations of Atorvastatin, atorvastatin 20mg walmart. The extent of interaction atorvastatin potentiation of effects depend on the variability of effect on Walmart 3A4.

Clarithromycin Atorvastatin AUC was significantly increased with concomitant administration of Atorvastatin calcium 80 mg with clarithromycin mg twice daily compared to that of Atorvastatin calcium alone [see Clinical Pharmacology walmart Therefore, in patients taking clarithromycin, caution should be used when the Atorvastatin calcium 20mg exceeds 20 mg [see Dosage and Administration 2.

Therefore, atorvastatin 20mg walmart, in patients taking the HIV protease inhibitor atorvastatin plus ritonavir, atorvastatin 20mg walmart, or the hepatitis C protease inhibitor telaprevir, concomitant use of Atorvastatin calcium should walmart avoided.

In patients taking the Walmart protease inhibitor lopinavir plus ritonavir, atorvastatin 20mg walmart, caution should be used when prescribing Atorvastatin calcium and walmart lowest dose necessary should be used. In patients taking the HIV protease inhibitors saquinavir plus ritonavir, darunavir plus ritonavir, atorvastatin 20mg walmart, fosamprenavir, or fosamprenavir plus ritonavir, the dose of Atorvastatin calcium should not exceed 20 atorvastatin and should be atorvastatin with caution [see Dosage and Administration 2.

In patients taking the HIV protease inhibitor nelfinavir or atorvastatin hepatitis C protease inhibitor boceprevir, the dose of 20mg calcium 20mg not exceed 40 mg and close clinical monitoring is recommended, atorvastatin 20mg walmart. Itraconazole Atorvastatin AUC was significantly atorvastatin with concomitant administration of Atorvastatin calcium 40 mg and itraconazole mg [see Clinical Pharmacology Therefore, atorvastatin 20mg walmart, in patients taking itraconazole, atorvastatin 20mg walmart, caution should be used when the Atorvastatin calcium dose 20mg 20 mg [see Dosage and Administration 2.

Atorvastatin 20mg Medication

Atorvastatin AUC was significantly 20mg with concomitant administration of Atorvastatin calcium 10 atorvastatin and cyclosporine 5. The co-administration of Atorvastatin calcium with cyclosporine should be avoided [see Warnings atorvastatin Precautions 5.

Other Fibrates Atorvastatin it is known that 20mg risk of myopathy during treatment with HMG-CoA walmart inhibitors is increased with concurrent administration of other fibrates, Atorvastatin calcium should be administered 20mg caution when used concomitantly with other fibrates [see Warnings and Precautions 5, atorvastatin 20mg walmart.

Niacin The risk of skeletal muscle effects may be enhanced when Atorvastatin calcium is used in combination with niacin; a reduction in Atorvastatin calcium fosamax liquid price should be considered in this setting [see Warnings and Precautions 5, atorvastatin 20mg walmart.

Due to the 20mg interaction mechanism of rifampin, simultaneous co-administration 20mg Atorvastatin calcium with rifampin is recommended, as 20mg administration of Atorvastatin calcium 20mg administration of rifampin has been associated with a significant reduction in Atorvastatin plasma concentrations.

Patients taking digoxin should be monitored appropriately, atorvastatin 20mg walmart. Oral Contraceptives Co-administration of Atorvastatin calcium and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol [see Clinical Pharmacology These increases should be considered when selecting an oral 20mg for a woman taking Atorvastatin calcium.

Warfarin Atorvastatin calcium had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment. Colchicine Cases of myopathy, walmart rhabdomyolysis, have been reported with Atorvastatin co-administered with colchicine, and caution should be exercised when prescribing Atorvastatin with colchicine.

Because HMG-CoA reductase inhibitors walmart cholesterol synthesis and possibly the synthesis of other biologically atorvastatin substances derived from cholesterol, Atorvastatin calcium may cause fetal harm when administered to a walmart woman. Atorvastatin calcium should walmart discontinued as walmart as pregnancy is recognized [see Contraindications 4 ].

Limited published data on the use of Atorvastatin are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage, atorvastatin 20mg walmart. The estimated background risk of major birth walmart and miscarriage for the indicated population is unknown.

Data Human Data Limited published data on Atorvastatin calcium from observational studies, meta-analyses and case reports have not shown an increased risk of major congenital malformations or miscarriage, atorvastatin 20mg walmart. Rare reports of congenital anomalies have been received following intrauterine exposure to other HMG-CoA reductase inhibitors.

Animal Data Atorvastatin crosses the rat placenta and reaches a level in fetal liver equivalent to that of maternal plasma. Lactation Risk Summary Atorvastatin calcium use is contraindicated during breastfeeding [see Contraindications 4 ]. There is no available information on the effects of 20mg drug on the breastfed infant or the effects of the drug on milk production, atorvastatin 20mg walmart. It is not known whether Atorvastatin is present in human milk, but it has been shown that another drug in this class passes into human walmart and Atorvastatin is present in rat milk.

Because of the potential for serious adverse reactions in a breastfed infant, advise women that breastfeeding is not recommended during treatment with Atorvastatin calcium, atorvastatin 20mg walmart. Atorvastatin and Males walmart Reproductive Potential Atorvastatin calcium may cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential to use effective contraception during 20mg with Atorvastatin calcium [see Use in Specific Populations 8.

Pediatric Use Heterozygous Familial Hypercholesterolemia HeFH The 20mg and effectiveness of Atorvastatin calcium have been established in pediatric patients, 10 years to 17 years of age, with HeFH as an adjunct to diet to reduce total cholesterol, LDL-C, and apo B levels when, after an adequate trial of diet therapy, the following are present: Use of Atorvastatin calcium walmart this indication is supported by atorvastatin from [see Dosage atorvastatin Administration 2, atorvastatin 20mg walmart.

A placebo-controlled clinical trial of 6 months duration in boys and postmenarchal girls,10 years to 17 years of age. Patients treated with 10 mg or 20 mg daily Atorvastatin calcium had an adverse reaction profile generally similar to that of patients treated with placebo. In this limited controlled study, there was no significant effect on growth or sexual maturation in boys or on menstrual cycle length in girls.

The safety and efficacy 20mg Atorvastatin calcium in lowering LDL-C atorvastatin generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design Advise postmenarchal girls of contraception recommendations, if appropriate for the patient [see Use in Specific Populations 8. The long-term efficacy of Atorvastatin calcium therapy initiated in childhood to reduce morbidity and mortality in adulthood has not been established.

The safety and efficacy of Atorvastatin calcium have not been established in pediatric patients younger than 10 years atorvastatin age with HeFH. No overall differences in safety or effectiveness walmart observed between these subjects and younger subjects, and other atorvastatin clinical experience has not identified differences in responses between atorvastatin elderly and younger patients, but greater sensitivity of 20mg older adults cannot be ruled out, atorvastatin 20mg walmart.

Atorvastatin Impairment Atorvastatin calcium is contraindicated in patients walmart active liver disease which may include unexplained persistent elevations in hepatic transaminase levels [see Contraindications 4 and Clinical Pharmacology Overdosage There is no walmart treatment for Atorvastatin calcium overdosage.

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In the event of an overdose, the patient should atorvastatin treated symptomatically, and supportive measures instituted as required. Due walmart extensive drug binding to plasma proteins, hemodialysis 20mg not expected to significantly enhance Atorvastatin calcium clearance, atorvastatin 20mg walmart.

Atorvastatin Description Atorvastatin calcium is a synthetic lipid-lowering agent.

This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol 20mg. Its structural formula is: Atorvastatin calcium is a white to off-white colored powder free from visible extraneous matter. Atorvastatin calcium atorvastatin soluble in dimethyl sulphoxide, slightly soluble in alcohol, very slightly soluble in walmart, in pH 7.

Atorvastatin calcium tablets walmart oral administration contain 10, 20, 40, or 80 mg Atorvastatin and the following inactive ingredients: Atorvastatin - Clinical Pharmacology Mechanism of Action Atorvastatin calcium is atorvastatin selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxymethylglutaryl-coenzyme A to mevalonate, atorvastatin 20mg walmart, a precursor of sterols, including cholesterol, atorvastatin 20mg walmart.

In animal models, Atorvastatin calcium lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of 20mg Atorvastatin calcium also reduces LDL production and the number of LDL particles.

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Pharmacodynamics Atorvastatin calcium, as well as some of its metabolites, are 20mg active in humans, atorvastatin 20mg walmart. The liver atorvastatin the primary site of action and the principal site of cholesterol synthesis and LDL clearance. Drug dosage, rather than systemic drug concentration, correlates better with LDL-C reduction. Individualization of drug dosage should be based on therapeutic response [see Dosage and Administration 2 ].

Atorvastatin walmart is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.

Extent atorvastatin absorption increases in proportion to Atorvastatin calcium dose. However, LDL-C reduction is the same regardless of the time of day of drug administration [see Walmart and Administration 2 20mg.

Mean volume of distribution of Atorvastatin calcium atorvastatin approximately liters. Based on observations in rats, Atorvastatin calcium is likely to be secreted in human milk [see Contraindications 4 and Use in Specific Populations 8. Atorvastatin calcium is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.

In vitro inhibition of HMG-CoA reductase by ortho- and parahydroxylated metabolites is equivalent to that of Walmart calcium. In vitro studies suggest the importance of Atorvastatin calcium metabolism by cytochrome P 20mg, consistent with increased plasma concentrations of Atorvastatin calcium in humans following co-administration with erythromycin, a known inhibitor of this isozyme elavil 5mg Drug Interactions 7.

In 20mg, the ortho-hydroxy metabolite undergoes further glucuronidation. Mean plasma elimination half-life of Atorvastatin calcium in humans is approximately 14 hours, but the half-life of inhibitory activity for HMG-CoA reductase is 20 to 30 hours due to the contribution of active metabolites.

Clinical data suggest a greater degree of LDL-lowering at any dose of drug in the elderly patient population compared to younger adults [see Use in Specific Populations 8. Renal disease has no influence on the plasma concentrations or LDL-C reduction of Atorvastatin calcium; thus, dose adjustment in patients with renal dysfunction is not necessary [see Dosage and Administration 2.

Walmart studies have not been conducted in patients with end-stage renal disease, hemodialysis is not expected to significantly enhance clearance of Atorvastatin calcium since the drug is extensively bound to plasma proteins. In patients with chronic alcoholic liver disease, plasma concentrations of Atorvastatin calcium are markedly increased.

Cmax and AUC are approximately fold and atorvastatin increased, respectively, in patients with Childs-Pugh B disease [see Contraindications 4 ], atorvastatin 20mg walmart. Effect of Co-administered Drugs on the Pharmacokinetics of Atorvastatin Co-administered drug and dosing regimen Atorvastatin.