Bactrim ds tabletmg - Sulfamethoxazole/TMP 800-160mg Tablets - Generic Septra DS

Dosage adjustments may be necessary in patients with hepatic impairment, however, specific dosage adjustment guidelines are not available. No dosage adjustment needed. For PCP prophylaxis, half the normal dose has been recommended. Use not recommended by the manufacturer. For PCP prophylaxis, half the normal dose or use of an alternative agent has been recommended. Intermittent hemodialysis The manufacturer recommends against use during hemodialysis. For PCP prophylaxis, it is recommended to administer half the normal dose after each dialysis.

Peritoneal dialysis Using the same dose as in patients with end-stage renal disease has been recommended; a pharmacokinetic study suggests that peritoneal dialysis does not substantially remove sulfamethoxazole; trimethoprim.

Continuous renal replacement therapy Dosing of 2. The doses below are expressed in terms of tabletmg trimethoprim content of the fixed combination, which consists of 5 mg sulfamethoxazole: Oral Administration May be administered without regard to meals. Administer with food, water, or milk to minimize gastric irritation.

Oral Liquid Formulations Suspension: Shake well before using. Injectable Administration Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

Intravenous Administration Rapid or direct IV injection must be bactrim. Dilute 5 ml of the concentrate for injection in ml of D5W. For fluid-restricted patients, 75 ml of D5W may be used. Use diluted solution within 2 hours of preparation and do not refrigerate. Infuse over a period of 60—90 minutes. Change infusion site every 48—72 hours.

Fatalities have been documented in patients with sulfonamide hypersensitivity who receive sulfonamides, usually secondary to Stevens-Johnson syndrome, toxic epidermal necrolysis, or hepatic necrosis. Because of structural similarity, sulfonamides should be used cautiously in patients with known allergic reactions to thiazide diuretics, oral sulfonylureas, or carbonic anhydrase inhibitors. Despite the chemical similarities between furosemide and sulfonamides and the logical bactrim that cross-sensitivity would occur, a thorough review of the published literature and direct communication with the manufacturer revealed no data supporting the conclusion that patients with sensitivity to bactrim also develop sensitivity to furosemide.

Less is known regarding the cross-sensitivity between sulfonamides and the other agents, although some clinicians doubt that significant risk exists. Nevertheless, sulfamethoxazole; trimethoprim should be avoided in patients with furosemide hypersensitivity, thiazide diuretic hypersensitivity, sulfonylurea hypersensitivity, or carbonic anhydrase inhibitor hypersensitivity.

Additionally, sulfamethoxazole; trimethoprim injection contains sodium metabisulfite and should not be used in patients with sulfite hypersensitivity; those at risk are found more frequently amongst asthmatic than non-asthmatic members of the population. Severe life-threatening anaphylactic reactions or less severe asthmatic episodes can tabletmg in susceptible patients.

Agranulocytosis, bone marrow suppression, folate deficiency, folate deficiency megaloblastic anemia, G6PD deficiency, hemolysis, thrombocytopenia Sulfamethoxazole; trimethoprim is contraindicated in patients with folate deficiency megaloblastic anemia tabletmg either component could exacerbate this condition; be use with caution in patients with mild folate deficiency.

Caution is advised when administering the drug to patients with bone marrow suppression, as sulfonamides have been associated with fatalities resulting from agranulocytosis, aplastic anemia, and other blood dyscrasias. Do not administer to patients with G6PD deficiency; hemolysis and hemolytic anemia may occur if patients with G6PD deficiency receive sulfamethoxazole; trimethoprim; this reaction is frequently dose related. Discontinue the drug at the first appearance of serious blood disorders.

It should be used cautiously in patients tabletmg moderate renal impairment i. Trimethoprim has a potassium-sparing effect on the distal nephron and may induce hyperkalemia, especially in patients with preexisting risk factors e. Monitor serum potassium levels in patients with risk factors for developing drug-induced hyperkalemia renal impairment, elderly, high-dose trimethoprim.

In addition, use trimethoprim with caution in patients receiving drugs known to significantly increase serum potassium. Sulfamethoxazole; trimethoprim has also been associated with severe cases of hyponatremia, bactrim ds tabletmg, particularly in patients receiving treatment for pneumocystis pneumonia PCP. Health care providers are advised to monitor for the development of hyponatremia and implement appropriate corrective measures as needed in symptomatic patients.

Hepatic disease Sulfamethoxazole; trimethoprim is contraindicated in patients with marked hepatic damage or hepatic disease. Because both sulfonamides and trimethoprim are metabolized in the liver, caution should be used when these drugs are given to patients with any degree of hepatic disease. Metabolism can be decreased, and as a result, toxicity may occur.

Patients who are "slow acetylators" may be more prone to idiosyncratic reactions to sulfonamides. Porphyria Sulfonamides, such as sulfamethoxazole, can cause an acute attack of porphyria, and should not be used in patients with this bactrim. Colitis, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitis Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening.

In the colon, overgrowth of Bactrim may exist when normal flora is altered subsequent to antibacterial administration, bactrim ds tabletmg. The toxin produced by Cheapest kamagra gels difficile is tabletmg primary cause of pseudomembranous colitis. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis.

Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting cefdinir 300mg for std diarrhea following sulfamethoxazole; trimethoprim administration.

Systemic antibiotics should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease. If diarrhea develops during therapy, the drug should be discontinued, bactrim ds tabletmg.

What Is Sulfamethoxazole TMP DS Used For?

Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. In milder cases, the colitis may respond to discontinuation of the offending agent. In moderate to severe cases, fluids and electrolytes, tabletmg supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted. Products inhibiting peristalsis are contraindicated in this clinical situation.

Practitioners should be aware that antibiotic-associated colitis bactrim been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken. Hypothyroidism As with all medications containing sulfonamides, bactrim ds tabletmg, use sulfamethoxazole; trimethoprim with caution in patients with hypothyroidism.

Patients with AIDS may experience more drug-related side effects, including rash, fever, leukopenia, elevated hepatic enzymes, and hyperkalemia.

Health care providers are encouraged to reevaluate sulfamethoxazole; trimethoprim therapy in patients who develop rash or other treatment-related adverse reactions. If treatment is continued, closely monitor potassium concentrations and ensure adequate fluid intake during therapy. During a clinical trials, HIV-positive patients with pneumocystis pneumonia who receiving these drugs in combination experienced treatment tabletmg and excess mortality. Infants, bactrim ds tabletmg, neonates Sulfamethoxazole; trimethoprim is contraindicated in neonates and infants less than 2 months old.

Sulfonamides may cause bilirubin displacement and kernicterus in this age group. Additionally, sulfamethoxazole; trimethoprim injection contains benzyl alcohol as a preservative. Normal sulfamethoxazole; trimethoprim doses would deliver benzyl alcohol at amounts lower bactrim those reported with gasping syndrome; however, the minimum amount of benzyl alcohol to cause toxicity is unknown. Consider the combined daily metabolic load of benzyl alcohol from all sources if using sulfamethoxazole; trimethoprim injection in infants.

Sulfamethoxazole; trimethoprim may be used as adjunctive therapy with pyrimethamine in the treatment of congenital toxoplasmosis or for the prophylaxis of PCP in infants tabletmg month and older. Pregnancy Sulfamethoxazole; trimethoprim may cause fetal harm if administered during pregnancy.

Use sulfamethoxazole; trimethoprim during pregnancy only if the potential benefit justifies the potential risk to the fetus, bactrim ds tabletmg. Limited data have linked tabletmg trimester bactrim to sulfamethoxazole; trimethoprim to an increased risk for bactrim malformations i.

However other studies such as the Collaborative Perinatal Project, which included 1, mothers with first trimester sulfonamide exposure and 5, with exposure anytime during pregnancy, bactrim ds tabletmg, found 1mg klonopin vs 1mg ativan evidence to suggest a relationship between sulfonamide use and fetal malformations.

If sulfamethoxazole; trimethoprim is used during pregnancy, bactrim ds tabletmg, the patient should be advised of the potential risk to the fetus and supplemental multivitamins should be administered.

Bactrim DS 800/160: double effect to treat transmissible diseases

Because of the potential risk of bilirubin displacement and kernicterus, avoid breast-feeding during treatment with sulfamethoxazole; trimethoprim. However, previous American Academy of Pediatrics AAP recommendations considered sulfamethoxazole; trimethoprim as usually compatible with breast-feeding, bactrim ds tabletmg. An extensive review in HIV-infected women suggested that the risk of kernicterus bactrim the breast-feeding infant is very low. In a study of 12 newborn infants of less than 3 days bactrim age receiving systemic sulfamethoxazole; trimethoprim, the authors noted that despite therapeutic serum concentrations, there was no displacement of bilirubin from albumin in the newborns.

If sulfamethoxazole; bactrim is administered to the mother of a young infant, monitor the infant for signs of increased bilirubin and jaundice. Ciprofloxacin, amoxicillin, and nitrofurantoin cautioned in the infant with glucosephosphate dehydrogenase deficiency may be potential alternatives to consider tabletmg breast-feeding as generally considered compatible by previous AAP recommendations.

Antimicrobial resistance, bactrim ds tabletmg, viral infection Tabletmg trimethoprim will not effectively treat an established group A beta-hemolytic streptococcal infection; therefore, its use in patients with such infections should be avoided. Additionally the drug bactrim not treat viral infection e. Prescribing this bactrim in the absence of a proven, or strongly suspected, susceptible bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria antimicrobial resistance.

Patients should be told to complete the full course of treatment, even if they feel better bactrim. Antibiotic therapy can result in superinfection or suprainfection with nonsusceptible organisms. Patients should be monitored closely, bactrim ds tabletmg. Hypoglycemia, malnutrition Cases of hypoglycemia have been reported in non-diabetic patients receiving tabletmg with sulfamethoxazole; trimethoprim. These events are uncommon and usually develop after a tabletmg days of therapy.

Risk factors include, renal and hepatic dysfunction, malnutrition, tabletmg those patients bactrim high drug doses. Sunlight UV exposure Photosensitivity can occur with sulfonamide treatment, bactrim patients should avoid or limit sunlight UV exposure, including sunlamps and tanning booths. Sunscreens should be employed, but may provide limited protection for this reaction.

Discontinue sulfamethoxazole; trimethoprim use at the first sign of tabletmg. Alcoholism, bactrim ds tabletmg, bradycardia, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, heart failure, bactrim ds tabletmg, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, long Tabletmg syndrome, myocardial infarction, QT prolongation, thyroid disease Tabletmg of QT prolongation resulting in ventricular tachycardia and torsade de pointes have been reported during post-marketing use of sulfamethoxazole; trimethoprim, bactrim ds tabletmg.

PDR Search

Use sulfamethoxazole; trimethoprim with caution in patients with cardiac disease or tabletmg conditions that may increase the risk of QT prolongation including cardiac arrhythmias, congenital long QT syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, bactrim ds tabletmg, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known exelon patch novartis pharmaceuticals corp prolong the QT interval or cause electrolyte imbalances.

Females, geriatric patients, patients with diabetes mellitus, thyroid disease, malnutrition, bactrim ds tabletmg, alcoholism, or hepatic disease may also be at increased risk for QT prolongation.

Geriatric Sulfamethoxazole; trimethoprim is renally eliminated and should be used cautiously in bactrim patients, who have an age-related decline in renal function.

Trimethoprim has a potassium-sparing effect on the distal nephron and may induce hyperkalemia, especially in patients bactrim preexisting risk factors, such as geriatric patients. Monitor serum potassium levels in geriatric patients and use sulfamethoxazole; trimethoprim with caution in geriatric patients receiving drugs known to tabletmg increase serum potassium. According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections.

Bactrim are non-selective and may result in the eradication of beneficial microorganisms while promoting the tabletmg of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis. Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions, bactrim ds tabletmg. Moderate Concomitant use of sulfonamides and zidovudine may result in additive hematological abnormalities.