Pediatric cystic fibrosis case study answers
Genetic Science Learning Center. (, December 1) Gene Therapy Case Study: Cystic Fibrosis. Retrieved November 17, , from mixedmartialartscamp.com
How do you develop a nursing care plan?
What nursing care plan book do you recommend helping you develop a nursing care plan? This care plan is listed to give an example of how a Nurse LPN or RN may plan to treat a patient with those conditions.
Do not treat a patient based on this care plan. Care Plans are often developed in different formats.
Some hospitals may have the information displayed in digital format, or use pre-made templates. The most important part of the care plan is the content, as that is the foundation on which you will base your care.
Nursing Care Plan for: Otherwise, scroll down to view this completed care plan. A 15 year old male is admitted with pneumonia. Describe a way that a doctor could take a measurement of FEV.
Why do you think it was important to have placebos in both of these studies? Which graph do you think provides the most compelling evidence for the effectiveness of Ivacaftor.
Take a look at the mutations that can occur in the cell membrane protein from Part III. For which mutation do you think Ivacaftor will be most effective. Would you sign Zoey up for clinical trials based on the evidence?
What concerns would a parent have before considering an experimental drug? Weyland calls a week later to inform the parents that genetic tests show that Zoey chromosomes show that she has two copies of the Fdel mutation.
"Common Pediatric Respiratory Problems" by Monica Kleinman, MD for OPENPediatricsThis mutation, while the most common type of CF mutation, is also one that is difficult to treat with just Ivacaftor. There are still some options for treatment.
Lumacaftor In people with the most common CF mutation, Fdel, a series of problems prevents the CFTR protein from taking its correct shape and reaching its proper place on the cell surface.
The cell recognizes the protein as not normal and targets it for degradation before it makes it to the cell surface.
In order to treat this problem, we need to do two things: A new answer of research uses ex-vivo studies, where rectal organoids mini-guts were grown from rectal biopsies of the patient that would be treated jyj essay their rooms the drug.
Ex-vivo experiments are personalized medicine, each person may have cystic correctors and potentiators evaluated using their own pediatric organoids. The fibrosis below shows how each drug works for 8 different cases 1- 8. Swelling in the organoid indicates the the channels within the cell membrane are allowing material to pass.
Compare ex-vivo trials to in-vitro trials.