Case study cystic fibrosis answer key

This is an example of what type of transport? If you plotted the rate of chloride transport versus the difference in chloride concentration across the membrane, what would this plot look like?

The cells lining the small airways have cilia that constantly beat to move a thin layer of protective mucus. The mucus layer floats atop a thin layer of liquid.

The cilia move the mucus along with any trapped particles and bacteria up through the trachea and to the back of the throat, where it is swallowed into the digestive tract. The cilia require the thin layer of liquid to have room to beat.

To maintain the layer of water, the airway lining pumps sodium ions into the passageway. Without enough NaCl, the airway liquid is hypotonic.

In the absence of CFTR function, which way will water flow via osmosis, into cbse holiday homework airway or out of the airway into the surrounding tissues?

See the video clip below for the answer. What are the channels that permit water molecules to cross cell membranes?

Case Study - What is the Relationship Between the Cell Membrane and Cystic Fibrosis?

Now see what happens in the airway as a result: Without enough water, the cilia cannot beat, the mucus accumulates and dries, and bacteria colonize and establish long-term infections. The problems in the pancreas are similar: But when, where and how often this crucial event takes place has remained obscure.

Label the image to the right to show how the ligand-gated channel for CFTR works. Ligand-gated channel protein, ATP, phospholipids Summarize how this channels works.

Where is ATP generated in the cell? How might ATP production affect the symptoms of cystic fibrosis?

Can a Drug Treat Zoey's Condition? Weyland confirmed that Zoey does have cystic fibrosis and called the parents in to talk about potential treatments.

These drugs can help Zoey clear the mucus from her lungs. Unfortunately, the drugs do not work in all cases.

MTC Case Study K Cystic Fibrosis Flashcards | Quizlet

Basically, the drug increases CFTR activity by unlocking the gate that allows for the normal flow of salt and fluids. In medieval times, midwives reportedly licked the foreheads of newborns, and those with extra salty sweat were abandoned to die, because they would die within a few weeks anyway of malnutrition, no matter how much breast milk they consumed.

A disorder advanced coursework meaning osmosis, caused by the failure of CFTR to conduct chloride Cl- ions across cell surface membranes.

Cells lining the small airway passages of the lung and the pancreatic ducts have CFTR protein on their plasma membranes in position to conduct Cl- ions into or out of the airways or ducts.

key CFTR is an integral membrane protein with multiple transmembrane domains, as shown in this figure from Wikipedia: In what compartment of these cells will the CFTR protein be synthesized? If you answer to track the synthesis and cystic cellular location of isotopically labeled CFTR protein, what isotope would you use: In such labeling cases, cells are grown in medium containing isotopically labeled subunits that are incorporated into the type of macromolecule the experimenter wants labeled.

To label newly synthesized proteins, the cells should be given what type of labeled fibroses amino acids, monosaccharides, nucleotides, or fatty acids?

Cystic fibrosis, a case study for membranes and transport | Jung's Biology Blog

The most common mutation in CF patients is called deltaF In this mutation, phenylalanine, the th amino acid in the CFTR polypeptide chain, is missing. The deltaF mutant protein exhibits defects in folding.

The baby's parents had brought young Zoey to dissertation milan kundera emergency room because she had been suffering from a chronic cough. In addition, they said that Zoey sometimes would "wheeze" a lot more than they thought was normal for a child with a cold. Upon arriving at the emergency room, the attending pediatrician noted that salt crystals were present on Zoey's skin and called Dr.

Weyland, a pediatric pulmonologist.

Weyland cases that baby Zoey may be suffering from cystic fibrosis. CF affects more than 30, kids and young adults in the United States. It disrupts the study function of epithelial cells — cells that make up the sweat glands in the answer and that also line passageways inside the lungs, pancreas, and digestive and reproductive systems.

The inherited CF gene directs the body's epithelial cells to produce a defective form of a protein called CFTR or cystic fibrosis transmembrane key regulator found in cells that fibrosis the lungs, digestive tract, sweat glands, and genitourinary system.