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Cancer treatment[ edit ] The 5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting.
Postoperative[ edit ] A number of medications including ondansetron ondansetron to be effective in controlling postoperative nausea and vomiting. It is more effective than metoclopramideand less sedating than cyclizine or droperidol.
Pregnancy[ edit ] Ondansetron is used off-label to price morning sickness and hyperemesis gravidarum of pregnancy. It is typically used after trials of other drugs have failed, ondansetron price usa. A study of overpregnancies in Denmark found that ondansetron during pregnancy was not associated with a significantly increased risk of spontaneous abortionstillbirthmajor birth defectpreterm birthlow birth weightondansetron price usa, or small for usa age.
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Its use reduced price admissions, but was also associated with higher rates of ondansetron visits to the emergency department. Furthermore, ondansetron price usa, patients who had initially received ondansetron were more likely to be admitted on the return visit usa patients who had usa received ondansetron price. However, this effect may simply be due to the agent being used more frequently in patients who present with more severe illness.
Its use was not found to mask serious diagnoses, ondansetron price usa. As such, little data are available to guide dosage recommendations. The use of ondansetron has not been studied in ondansetron older than 75 years of age, and it is not known if dosage should be adjusted for these patients.
In these patients, ondansetron is cleared from the body at half to one-third the rate as in healthy patients. The concentration of ondansetron in body tissues as opposed to plasma is also higher than in healthy patients.
Constipation, diarrhea, dizziness, and headache are the most commonly reported side effects. Anecdotally, ototoxicity has also been reported if injected too quickly. Although this may happen in any price with any formulation, the risk is most salient with the injectable intravenous form of the drug, and increases with dose. Oral dosing recommendations remain intact, including the recommendation of a single celebrex best prices usa dose when indicated.
Electrolyte imbalances should be corrected before the use of injectable ondansetron.
An antidote to ondansetron is not known, ondansetron price usa. The 5-HT3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. Serotonin is released by usa enterochromaffin cells of the small intestine in response to chemotherapeutic agents and may stimulate vagal afferents via 5-HT3 receptors ondansetron initiate the vomiting reflex.
It is thought that ondansetron's antiemetic action is mediated mostly via price of vagal afferents with a minor contribution from antagonism of central receptors, ondansetron price usa.
Zofran ODT (Ondansetron ODT)
It was granted another divisional patent in November Researchers examined 84 trials, ondansetron price usa, with 11, patients receiving ondansetron, published usa and September The number needed to treat NNT to prevent vomiting within 24 hours was 9, ondansetron price usa. In the three duplicated reports, the Ondansetron was significantly lower at 3.
When all 25 reports price combined, the apparent NNT improved to 4.