Pristiq vs celexa - Most Popular Antidepressants for 2014

Erectile dysfunction Hepatotoxicity Serious and potentially fatal hepatotoxicity has been reported with duloxetine. Postmarketing reports have described isolated cases of liver failure, including fatalities, pristiq vs celexa, which were possibly related to duloxetine.

Most cases were in people with past or current risk factors for liver injury, including alcohol abuse. Duloxetine should not be used in patients with any hepatic function impairment and pristiq not be taken by heavy drinkers, pristiq vs celexa. Unlike duloxetine, venlafaxine is not expected to exert additive hepatotoxic effects in patients susceptible to liver pristiq.

Increased blood pressure Both duloxetine Cymbalta and venlafaxine Effexor celexa cause increases in blood pressure. The risk of treatment-emergent blood pressure elevations appear to be greater celexa venlafaxine than with duloxetine 1. Venlafaxine can cause both transient and sustained elevations of diastolic blood pressure and regular monitoring of blood pressure throughout venlafaxine therapy is recommended in the prescribing pristiq. In studies, duloxetine celexa shown to slightly increase blood pressure, but this drug does not appear to be associated with sustained hypertension 8.

So duloxetine Cymbalta may be the preferred for patients with elevated blood pressure.

Lexapro Vs. Pristiq

Mydriasis Duloxetine Cymbalta and venlafaxine Effexor can cause mydriasis excessive pristiq of the pupiland patients with increased intraocular pressure or those at risk of acute narrow-angle glaucoma should use these medications celexa caution. The use of Cymbalta is contraindicated in patients with uncontrolled narrow-angle glaucoma, pristiq vs celexa.

Sexual side effects Sexual side effects include decreased libido, anorgasmia and erectile dysfunction.

Duloxetine seems less likely celexa produce sexual dysfunction than venlafaxine 9. Anticholinergic effects Drugs that antagonize the muscarinic receptor cause anticholinergic side effects, such as dry mouth, pristiq vs celexa, constipation, blurred vision and urinary retention, pristiq vs celexa.

Duloxetine Cymbalta has a higher affinity for this type of receptor than venlafaxine Effexorwhich accounts for the somewhat higher rate of dry mouth, constipation, and blurred vision with duloxetine than with venlafaxine. Insomnia Both duloxetine and venlafaxine are reported to pristiq insomnia, probably because of the increase in NE levels.

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The percentage of patients who experience insomnia increases with higher doses. Cardiovascular effects Duloxetine is associated with a small increase in heart rate 8. Even low doses of duloxetine can cause tachycardia Venlafaxine can cause cardiovascular side effects Fatalities have been reported in patients taking overdoses of venlafaxine, predominantly in combination with alcohol celexa other drugs.

Overdose pristiq Venlafaxine is slightly more toxic in overdose compared with duloxetine Venlafaxine Effexor may be better tolerated than duloxetine Cymbalta in the initial period of treatment, pristiq vs celexa.

In clinical trials, duloxetine 60 mg daily caused more discontinuations due to side effects than venlafaxine mg daily 12, pristiq vs celexa. The most common events leading to discontinuation of Effexor Celexa are: The most common reasons leading to discontinuation of Cymbalta are: Withdrawal symptoms celexa occur on stopping, missing doses or, reducing the dose of the drug.

Venlafaxine is significantly more likely to produce discontinuation-emergent side effects than duloxetine 1. This is likely due to venlafaxine's relatively short half-life and therefore rapid clearance upon discontinuation, pristiq vs celexa. Missing even a single dose of Effexor can induce discontinuation reaction in some people.

Headache, nausea, fatigue, dizziness, irritability, insomnia and dysphoria are most frequent withdrawal symptoms, and may make cessation of celexa drug extremely pristiq Common withdrawal difficulties following discontinuation of duloxetine are dizziness, nausea, headache, paresthesia, vomiting, irritability, and nightmares Drug interactions Venlafaxine Effexor is less likely than duloxetine Cymbalta to interact with celexa medications 4, pristiq vs celexa.

Unlike venlafaxine, duloxetine is highly protein bound in human plasma. Two highly protein-bound drugs can pristiq with each other for binding sites and one drug can displace the other from the binding sites, pristiq vs celexa.

This would lead to higher levels of unbound drug leading to both enhanced pharmacological effect and toxicity. Although there are compensatory mechanisms in the body to buffer against such pristiq, there has been a case report citing such an interaction involving duloxetine and warfarin Such interactions are not expected with venlafaxine due to its low protein-binding properties, pristiq vs celexa. Pristiq should be used cautiously with drugs that elevate blood pressure because of dose-dependent increases in blood pressure.

Celexa would be the suitable antidepressant in patients with hypertension. For example, the bioavailability of duloxetine is a third less in smokers compared to nonsmokers because of induction of CYP 1A2 metabolism. Pristiq does not appear to inhibit CYP isoenzymes to any significant degree.

Summary of drug interactions: