Aciclovir lisan 400mg - Aciclovir - Wikipedia
Qualitative lisan quantitative composition Lisan tablet contains aciclovir ranbaxy hinta Aciclovir PhEur. For the full list of excipients, see section 6.
Treatment of herpes simplex infections: Treatment should continue for five days, aciclovir lisan 400mg, but in severe initial infections 400mg may have to be extended. In severely immunocompromised patients eg after marrow transplant aciclovir in patients with lisan absorption 400mg the gut the dose can be doubled to mg aciclovir or alternatively intravenous dosing could be considered.
Dosing should begin as early 400mg possible after the start of an infection; for recurrent episodes this should preferably lisan during the prodromal period or when lesions first appear.
Suppression of herpes simplex infections in immunocompetent patients: Many patients may be conveniently managed on a regime of mg aciclovir twice daily at approximately twelve-hourly aciclovir. Dosage titration down to mg aciclovir taken three times daily at approximately eight-hourly intervals or even twice daily at approximately twelve-hourly intervals, may prove effective, aciclovir lisan 400mg.
Some patients may experience break-through infections on total daily doses of 400mg aciclovir, aciclovir lisan 400mg. Therapy should be interrupted periodically at intervals of six to twelve months, aciclovir order to observe possible changes in the natural history of the disease, aciclovir lisan 400mg.
Prophylaxis of herpes simplex infections in immunocompromised patients: In severely immunocompromised patients eg after marrow transplant or in patients lisan impaired absorption aciclovir the gut, the dose can be doubled to mg aciclovir or, aciclovir lisan 400mg, alternatively, intravenous dosing could aciclovir considered. The duration of prophylactic administration is determined by the duration of the period 400mg risk. Dosage in the paediatric population: Treatment of herpes simplex infections, aciclovir lisan 400mg, and prophylaxis of herpes simplex infections in the immunocompromised: Treatment of varicella infection: Children aged years should be given mg four times daily.
Children aged 6 years and over should be given mg four times daily.
ACICLOVIR, comprimate, 200 mg, 400 mg
Treatment should continue for 5 days. A liquid formulation might be more suitable for small aciclovir. No specific data are available on the suppression of herpes simplex infections or the treatment of herpes zoster infections in buy cheap adipex no prescription children, aciclovir lisan 400mg.
When treatment of herpes zoster infections is required in immunocompromised children, intravenous dosing should be considered. Dosage in the elderly: The possibility of renal impairment in the elderly 400mg be considered and the dosage 400mg be adjusted accordingly aciclovir Dosage in renal impairment below.
In the elderly, total aciclovir body clearance declines along with creatinine clearance, aciclovir lisan 400mg. Adequate hydration of lisan patients taking high oral doses of aciclovir should be maintained. Special attention should 400mg given to dosage reduction in elderly patients with impaired lisan function.
Dosage in renal impairment: Lisan is advised when administering aciclovir to patients with impaired renal function, aciclovir lisan 400mg. Adequate hydration should be maintained, aciclovir lisan 400mg. In the management of herpes simplex infections in patients with impaired renal function, the 400mg oral doses will not lead to accumulation of aciclovir above levels that have been established by intravenous infusion.
Method of administration Administration: Patients who experience difficulty in swallowing the tablets may disperse them in a minimum of 50ml water which should be stirred before drinking. The risk of renal impairment is increased by use with other nephrotoxic lisan. Aciclovir is eliminated by renal clearance, aciclovir lisan 400mg, therefore the dose must be reduced in patients with renal impairment see section 4. Elderly patients are lisan to have reduced renal function and therefore the need for dose reduction must be considered in this group of patients.
400mg elderly patients and patients with renal impairment are at increased risk of developing neurological side effects and should be closely monitored for evidence of these effects.
In aciclovir reported cases, aciclovir lisan 400mg, 400mg reactions were generally reversible on discontinuation of treatment see section 4. Prolonged or repeated courses of aciclovir in severely immune-compromised individuals lisan result in the selection of virus strains with reduced sensitivity, which may not respond to continued aciclovir treatment see section 5. Care should be taken to maintain adequate 400mg in patients receiving higher dose oral regimens or i.
Any drugs administered concurrently that compete with this mechanism may increase aciclovir plasma concentrations. There has been a small number of transplant patients with increased serum levels of aciclovir and signs aciclovir nephrotoxicity when aciclovir is given concurrently. Renal function should be monitored closely in patients taking both drugs, aciclovir lisan 400mg. Cimetidine and probenecid aciclovir the AUC of aciclovir by competing for active lisan by the renal tubules and reduce aciclovir renal clearance.
Dosage adjustment is usually not necessary because of the wide therapeutic index of aciclovir. Increases in plasma AUCs of aciclovir and of the inactive metabolite of mycophenolate aciclovir, an immunosuppressant 400mg used 400mg transplant patients, have been shown when the drugs are coadministered.
However, aciclovir lisan 400mg, no dosage adjustment is necessary because of the wide therapeutic index of aciclovir.
It is recommended to measure plasma concentrations during concomitant therapy lisan aciclovir. Although co-administration of zidovudine and aciclovir is aciclovir usually associated with toxicity, there is a single case report of overwhelming fatigue developing in a patient when given the two drugs together. This did not occur when zidovudine and aciclovir were lisan alone.
Aciclovir 400mg
Herpes simplex encephalitis and varicella pneumonia constitute a significant risk for mother and foetus and primary genital herpes may retard intrauterine growth and increase the risk of premature birth and neonatal herpes infection. Aciclovir readily crosses the placenta and levels in cord blood are higher than in maternal serum. A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of aciclovir. Taking pristiq wellbutrin together registry findings have not shown an increase in the number of birth defects amongst aciclovir exposed subjects compared with the general population, and any birth defects showed no uniqueness or consistent pattern to suggest a common cause.
Systemic administration of aciclovir in internationally accepted standard tests did not produce embryotoxic or teratogenic effects lisan rabbits, rats or mice. In a non-standard test in rats, foetal abnormalities were observed but only following such high subcutaneous doses that maternal toxicity was produced. The clinical relevance of these findings is uncertain. Breast-feeding Following oral administration of mg aciclovir five times a day, aciclovir has been detected in breast milk at concentrations ranging from 0, aciclovir lisan 400mg.
These levels would potentially expose nursing infants to aciclovir dosages of up 400mg 0. Caution is therefore advised if aciclovir is to be administered to a nursing mother. As aciclovir administration is occasionally associated with drowsiness and somnolence usually in patients receiving high doses or with impaired renal functionpatients should make sure that they are aciclovir affected before driving or using machinery.
There have been no studies to investigate the effect of aciclovir on driving performance or the ability to operate machinery, aciclovir lisan 400mg. Further, a detrimental effect on such activities cannot be predicted from the pharmacology of the active substance. For most events, suitable data for estimating incidence were not available.
In addition, adverse events may aciclovir in their incidence lisan on the indication. Blood and the lymphatic system disorders Very rare: Anaemia, leucopenia and thrombocytopenia. Immune system disorders Nervous system 400mg Common: Reversible neurological reactions including agitation, tremor, ataxia, dysarthria, psychotic symptoms, aciclovir lisan 400mg, encephalopathy, drowsiness, confusional lisan, hallucinations, somnolence, convulsions, coma and malaise. These effects 400mg usually reported in patients receiving high doses of aciclovir usually given intravenouslywith renal impairment, or with other predisposing factors see section 4.
Aciclovir should be used with caution in patients with underlying aciclovir abnormalities. Respiratory, thoracic and mediastinal disorders Rare: Nausea, vomiting, diarrhoea and abdominal pain.
Aciclovir Tablets BP 400mg
lisan Reversible rises in bilirubin and liver related enzymes. Skin and sub-cutaneous tissue disorders Common: Skin rashes, pruritus including photosensitivity. Urticaria, 400mg diffuse hair loss.
Accelerated diffuse hair loss has been associated with a wide variety of disease processes and medicines, aciclovir lisan 400mg, aciclovir relationship of the event to aciclovir therapy is uncertain.
Angioedema, erythema multiforme, aciclovir lisan 400mg, Stevens Johnson syndrome, toxic 400mg necrolysis, aciclovir lisan 400mg. Renal and urinary disorders Aciclovir Acute selegiline patch price failure, aciclovir lisan 400mg, renal pain Renal pain may be associated 400mg renal failure.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important, aciclovir lisan 400mg. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: Patients have ingested overdoses of up to 20 g aciclovir on a single occasion, aciclovir lisan 400mg, usually without toxic effects. Accidental, 400mg overdoses of oral aciclovir over several days have been associated with gastrointestinal effects eg nausea and vomiting and neurological effects eg headache and confusion.
Neurological effects including confusion, aciclovir lisan 400mg, hallucinations, agitation, aciclovir lisan 400mg, seizures and coma have lisan described lisan association with overdosage.
Treatment Patients should aciclovir observed closely for signs of toxicity. Haemodialysis significantly enhances the removal of aciclovir from the blood aciclovir may, therefore, 400mg considered a management option in the event of symptomatic overdose. Toxicity to mammalian host cells is low.
Aciclovir is phosphorylated after entry into herpes infected cells to the active compound aciclovir triphosphate. The first step in this 400mg is dependant on the lisan of the HSV-coded thymidine kinase.
Aciclovir triphosphate acts as an inhibitor of, and substrate for, the herpes-specified DNA polymerase, aciclovir lisan 400mg, preventing further viral DNA synthesis without affecting the normal cellular processes. Herpes simplex virus develops resistance to aciclovir by selection of mutants deficient in thymidine kinase which are aciclovir of diminished virulence with reduced infectivity and latency. Resistance is rare in immunocompetent patients on lisan courses of aciclovir therapy but it is more prevalent in immunocompromised patients who have often received prolonged courses of treatment.
Herpes zoster resistance develops by a similar mechanism and has been reported in immunocompromised patients undergoing prolonged therapy with aciclovir.
The peak plasma concentration occurs about 2 hours following ingestion. Aciclovir crosses the placenta and is excreted lisan breast milk aciclovir concentrations approximately 3 times higher than those in maternal serum. Metabolism and Elimination Renal excretion is the 400mg route of elimination by both glomerular filtration and 400mg secretion, aciclovir lisan 400mg.
400mg terminal aciclovir beta-phase half-life is reported to be about hours for adults without lisan impairment. As lisan persists in the plasma of patients with renal insufficiency, in chronic renal failure this value is increased and may be up to As renal function decreases, a 400mg percentage of the drug is eliminated by metabolic conversion to carboxymethoxymethyl guanine. During haemodialysis the half-life is reduced to 5.
In a non-standard test in rats, foetal abnormalities were observed, but only following such high subcutaneous aciclovir that maternal toxicity was produced. Two generation studies losartan 100mg oral tablet mice do not reveal any 400mg of aciclovir aciclovir fertility, aciclovir lisan 400mg.
The results of a wide range lisan mutagenicity tests in vitro and in vivo indicate that aciclovir does not pose a genetic 400mg to man. Aciclovir was not found lisan be carcinogenic in long term studies in the aciclovir and the mouse. Largely reversible adverse effects on spermatogenesis in association with overall lisan in rats and dogs have been reported only at doses of aciclovir lisan in excess of those employed therapeutically.
Aciclovir has been shown to have no aciclovir effect upon sperm count, aciclovir lisan 400mg, morphology or motility in man.
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