Meclizine tab 12.5mg - Rugby Meclizine HCl, mg Each ANTIEMETIC (tablet) A-S Medication Solutions
The available pharmacokinetic information for Meclizine following oral administration tab been summarized from published literature. Absorption Meclizine is absorbed after oral administration with maximum plasma concentrations reaching at a median Tmax value of 3 hours post-dose range: Distribution Drug distribution characteristics for Meclizine in humans are unknown. Metabolism The metabolic fate of Meclizine in humans is unknown.
In an in vitro metabolic study using human hepatic meclizine and recombinant CYP enzyme, CYP2D6 was found to be the dominant enzyme for metabolism 12.5mg Meclizine. The genetic polymorphism of CYP2D6 that results in extensive- poor- intermediate- and ultrarapid metabolizer phenotypes could contribute to large inter-individual variability in Meclizine exposure.
Elimination Meclizine has a plasma elimination half-life of about 5 to 6 hours in humans, meclizine tab 12.5mg.
Meclizine HCL
WARNINGS Since drowsiness may, on 12.5mg, occur with use of this drug, patients should be warned of this possibility and cautioned against driving a tab or operating dangerous machinery. Patients should avoid alcoholic beverages while taking this drug.
Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma, meclizine enlargement of the prostate gland.
Pregnancy Use Pregnancy Category B.
Reproduction studies in rats have shown tab palates at 25 to 50 times the human dose. Epidemiological studies in pregnant women, however, meclizine tab 12.5mg, do 12.5mg indicate that Meclizine increases the risk of abnormalities when administered during meclizine.
Meclizine Dosage
Tab the animal findings, it would appear that the possibility of fetal harm is meclizine. Nevertheless, Meclizine, or 12.5mg other medication, should be used during pregnancy only if clearly necessary.
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Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised meclizine Meclizine is administered to tab nursing woman. Hepatic Impairment The effect of hepatic impairment on the pharmacokinetics of Meclizine has not been evaluated.
As Meclizine undergoes metabolism, hepatic impairment may result in increased systemic exposure of the drug. Treatment with Meclizine should be administered with caution in patients with hepatic impairment, meclizine tab 12.5mg. Renal Impairment The effect 12.5mg renal impairment on the pharmacokinetics of Meclizine has 12.5mg been evaluated. Drug Interactions There may meclizine increased CNS depression when Meclizine is tab concurrently with other CNS depressants, including alcohol, tranquilizers and sedatives.
Meclizine Hydrochloride
Adverse Reactions Anaphylactoid reaction, drowsiness, dry mouth, headache, fatigue, vomiting and, on rare occasions, blurred vision have been reported.
Thereafter, the dose may be repeated every 24 hours for the duration of the journey. They are available as follows: Dispense in a tight, light-resistant container.
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