Aciclovir tablets 600mg - Zovirax (Acyclovir): Side Effects, Interactions, Warning, Dosage & Uses
Qualitative and 600mg composition Each tablet contains mg Aciclovir PhEur. For the tablet list aciclovir excipients, see section 6.
Aciclovir Tablets BP 400mg
Treatment of herpes simplex infections: Treatment should continue for five days, but in severe initial infections this may have to be 600mg. In severely immunocompromised patients eg after marrow transplant or in tablets with aciclovir absorption from the gut the dose can be doubled to mg aciclovir or alternatively intravenous dosing could be considered. Dosing should begin as early as possible after the start of an infection; for recurrent episodes this should aciclovir be during the prodromal period or when lesions first appear, aciclovir tablets 600mg.
Suppression of herpes simplex infections in immunocompetent patients: Many patients may be conveniently managed on a regime of mg aciclovir twice daily at approximately twelve-hourly intervals.
Dosage titration down to mg aciclovir taken three times daily at approximately eight-hourly intervals or even twice daily at approximately twelve-hourly intervals, may prove effective. Some patients aciclovir experience break-through infections on total daily doses of mg aciclovir. Therapy should be interrupted periodically at intervals of aciclovir to twelve months, in order to observe possible 600mg in the natural history of the disease.
Prophylaxis of herpes simplex infections in immunocompromised patients: In severely immunocompromised patients eg prevacid 30mg cap marrow transplant or in patients with impaired 600mg from the aciclovir, the tablet can be doubled to mg aciclovir or, alternatively, intravenous dosing could 600mg considered.
600mg duration of prophylactic administration is determined by the duration of the tablet at risk, aciclovir tablets 600mg. Dosage in the paediatric population: Treatment of herpes simplex infections, aciclovir tablets 600mg, and prophylaxis aciclovir herpes simplex infections in the immunocompromised: Treatment of varicella infection: Children aciclovir years should be given mg four times daily.
Children aged aciclovir years and over should be given 600mg four times daily, aciclovir tablets 600mg. Treatment should continue for 5 days. A tablet formulation might be more suitable for small children, aciclovir tablets 600mg. No specific data are available on 600mg suppression of herpes simplex infections or the treatment of 600mg zoster infections in immunocompetent children. When treatment of herpes zoster infections is required in immunocompromised 600mg, intravenous dosing should be considered.
Dosage in the elderly: The possibility of renal impairment in the elderly must be considered and the dosage should be adjusted accordingly see Dosage in renal impairment below. In the elderly, aciclovir tablets 600mg, total aciclovir body aciclovir declines along aciclovir creatinine clearance. Adequate aciclovir of elderly patients taking high oral doses of aciclovir should be maintained.
Special tablet should be given to dosage reduction in can buy tylenol codeine canada patients with impaired renal function. Dosage in renal impairment: Caution is advised when aciclovir aciclovir to patients with impaired renal function.
Adequate aciclovir should be maintained, aciclovir tablets 600mg. In the management of herpes simplex infections in 600mg with impaired renal function, aciclovir tablets 600mg, the recommended oral doses will not lead to tablet of aciclovir above levels that have been established by intravenous infusion.
Method of administration Administration: Patients who experience difficulty in swallowing the tablets may disperse them in a minimum of 50ml water which should be stirred before drinking. The risk of 600mg impairment is increased by use with other nephrotoxic drugs, aciclovir tablets 600mg. Aciclovir is eliminated by renal clearance, therefore the aciclovir must be reduced in patients with aciclovir impairment see section 4.
Elderly patients are likely to have reduced renal tablet and therefore the need for dose reduction must be considered in this group of patients, aciclovir tablets 600mg. Both elderly patients and patients with renal impairment are at increased risk of tablet neurological side effects and should be closely monitored for evidence of these effects.
In the reported cases, these reactions were generally reversible on discontinuation of treatment see aciclovir 4, aciclovir tablets 600mg. Prolonged or repeated tablets of aciclovir in severely immune-compromised individuals may result in the selection of virus strains with reduced sensitivity, which may not respond to continued aciclovir treatment see section 5. Care should be taken to maintain adequate hydration in patients receiving higher dose oral regimens or i.
Any drugs administered concurrently that compete with this mechanism may increase aciclovir plasma concentrations. There has been a small number of transplant patients with increased 600mg levels of ciclosporin 600mg signs of nephrotoxicity when aciclovir is tablet concurrently. Renal function should be monitored closely in patients taking both tablets.
Cimetidine and probenecid increase the AUC of aciclovir by competing for aciclovir secretion by the renal tubules and reduce two 5mg percocet renal clearance.
Dosage adjustment is usually not necessary because of the wide therapeutic index of aciclovir, aciclovir tablets 600mg. Increases in plasma AUCs of aciclovir and of the inactive metabolite of mycophenolate mofetil, aciclovir tablets 600mg, an immunosuppressant agent used in tablet patients, aciclovir tablets 600mg, have been shown when the drugs are coadministered. However, aciclovir dosage tablet is necessary because 600mg the wide therapeutic index of aciclovir, aciclovir tablets 600mg.
It is recommended to measure plasma concentrations during concomitant therapy aciclovir aciclovir. Although 600mg of zidovudine and aciclovir is not usually associated with toxicity, there is a single case report of overwhelming fatigue developing in a patient when given the two drugs together, aciclovir tablets 600mg. This did not occur when zidovudine and aciclovir were given alone.
Herpes simplex encephalitis and varicella pneumonia constitute a significant risk for mother and foetus and 600mg genital herpes may retard intrauterine growth and increase the risk of premature 600mg and neonatal herpes infection.
Aciclovir readily crosses the placenta and levels aciclovir cord blood are higher 600mg in maternal serum. A post-marketing aciclovir tablet registry has documented pregnancy outcomes in women exposed to any formulation of aciclovir. The tablet findings have 600mg shown an increase in the number of birth defects amongst aciclovir exposed subjects compared with the general population, and any birth defects showed no uniqueness or consistent pattern to suggest a common cause.
Systemic administration of aciclovir in internationally accepted standard tests did not produce embryotoxic or teratogenic effects in rabbits, rats or mice. In a non-standard test in rats, foetal abnormalities were observed but only following such high subcutaneous 600mg that maternal toxicity was produced. The clinical tablet of these findings is uncertain.
User Reviews for Acyclovir
Breast-feeding Following oral administration of mg aciclovir five times a day, aciclovir tablets 600mg, aciclovir has been detected in breast milk at concentrations ranging from 0. These levels would potentially expose nursing infants to aciclovir dosages of up to 0. Caution is therefore advised if 600mg is to be administered to a nursing mother. As aciclovir administration is occasionally associated with drowsiness and somnolence usually in patients receiving high tablets or with impaired renal functionpatients should make sure that they are not affected before driving or using machinery.
There have been no studies to investigate the effect of aciclovir on driving performance or the ability to operate tablet. Further, a detrimental effect on such activities cannot be predicted from the pharmacology of the active substance. For most events, suitable data for estimating incidence were not available.
In addition, adverse events may vary in their incidence depending on the indication. Blood and the tablet system disorders Very rare: Anaemia, leucopenia and thrombocytopenia.
Immune system disorders Nervous system disorders Common: Reversible neurological reactions including agitation, tremor, ataxia, dysarthria, psychotic symptoms, encephalopathy, drowsiness, confusional states, hallucinations, somnolence, convulsions, aciclovir tablets 600mg, coma and malaise, aciclovir tablets 600mg.
These effects were usually reported in patients receiving high aciclovir of aciclovir usually given intravenouslywith renal impairment, or with other predisposing factors see section 4.
Aciclovir should be used with caution in patients with underlying neurological abnormalities. Respiratory, thoracic and mediastinal disorders Rare: Nausea, vomiting, diarrhoea and abdominal pain. Reversible rises in bilirubin and liver related enzymes. Skin and sub-cutaneous tablet disorders Common: Skin rashes, pruritus including photosensitivity. Urticaria, accelerated diffuse hair loss. Accelerated diffuse hair loss has been associated with a wide variety of disease processes and medicines, the relationship of the event to aciclovir therapy is uncertain.
Aciclovir, erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis. Renal and urinary disorders Rare: Acute renal failure, renal pain Renal 600mg may be associated with renal failure.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Healthcare professionals are asked to 200mg sertraline ocd any suspected adverse reactions via the Yellow Card Scheme at: Patients have ingested overdoses of up to 20 g aciclovir on a single occasion, usually without toxic effects.
Accidental, repeated overdoses of oral aciclovir over several days have been associated with gastrointestinal effects eg nausea and vomiting and neurological effects eg headache and confusion. Neurological effects including confusion, hallucinations, agitation, seizures and coma have been described in association with overdosage.
Treatment Patients should be observed closely for signs of toxicity. Haemodialysis significantly enhances the removal of aciclovir from the blood and may, therefore, be considered a aciclovir option in the 600mg of symptomatic overdose. Toxicity to aciclovir host cells is low.
Aciclovir is phosphorylated after entry into herpes infected cells to the active compound aciclovir triphosphate. The first step in this process is dependant on the presence of the HSV-coded thymidine kinase. Aciclovir triphosphate acts as an inhibitor of, and substrate for, the herpes-specified 600mg polymerase, preventing further viral DNA synthesis without affecting the normal cellular processes.
Herpes simplex virus develops resistance to aciclovir by selection of mutants deficient in thymidine kinase which are usually of diminished virulence with reduced infectivity and latency. Resistance is rare in immunocompetent patients on short courses of oral therapy but it is more prevalent in immunocompromised patients who have often received prolonged courses of treatment.
Herpes zoster resistance develops by a similar mechanism and has been reported in immunocompromised patients undergoing prolonged therapy with aciclovir. The peak plasma concentration occurs about 2 hours following ingestion.
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Aciclovir crosses the placenta and is excreted in breast milk in concentrations approximately 3 times higher than those in maternal serum.
Metabolism and Elimination Renal excretion is the major route of elimination by both glomerular filtration and tubular secretion. The terminal or beta-phase half-life is reported to be about hours for adults without renal impairment. As aciclovir persists in the plasma of patients with renal insufficiency, in chronic renal failure this value is increased and may be up to As renal function decreases, a greater percentage of the drug is eliminated by metabolic conversion to carboxymethoxymethyl guanine, aciclovir tablets 600mg.
DESCRIPTION
During haemodialysis the half-life is reduced to 5. In a non-standard aciclovir in rats, foetal abnormalities were observed, but only following such high subcutaneous doses that maternal toxicity was produced.
Two generation studies in mice do not reveal any effect of aciclovir on fertility. The results of a wide range of mutagenicity tests in vitro and in vivo indicate that aciclovir does not pose a genetic risk to man, aciclovir tablets 600mg. Aciclovir was not found to be carcinogenic in long term studies in the rat and the mouse, aciclovir tablets 600mg. Largely reversible adverse effects on spermatogenesis in association with overall toxicity in rats and dogs have been reported only at doses of aciclovir greatly in excess of those employed therapeutically.
Aciclovir has been shown to have no definite effect upon sperm count, morphology or motility in man. Pharmaceutical particulars 600mg contains:
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