Atorvastatin 20mg generic - Atorvastatin (Generic Drug) combination List of Brand/ Trade Names | Medindia
Atorvastatin
A history of renal impairment may be a risk factor for the development of rhabdomyolysis. Such patients merit closer monitoring for skeletal muscle effects. The concomitant use of higher doses of atorvastatin with certain drugs such as cyclosporine and strong CYP3A4 inhibitors e. There have been rare reports of immune-mediated necrotizing myopathy IMNMan autoimmune myopathy, atorvastatin 20mg generic, associated with statin use.
IMNM is characterized by: Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing LIPITOR. The risk of myopathy during treatment with drugs in this class is increased with concurrent administration of cyclosporine, fibric acid derivatives, erythromycinclarithromycin, the hepatitis C protease inhibitor telaprevir, combinations of HIV protease inhibitors, including saquinavir plus ritonavir, lopinavir plus ritonavir, tipranavir plus ritonavir, darunavirplus ritonavir, fosamprenavir, and fosamprenavir plus 20mg, niacinor azole antifungals.
Physicians considering combined therapy with LIPITOR and fibric acid derivatives, erythromycin, clarithromycin, a combination ofsaquinavir plusritonavir, lopinavir plus ritonavir, darunavir plusritonavir, fosamprenavir, or fosamprenavir plus ritonavir,azole antifungals, or lipid -modifying doses of niacin should carefully weigh the generic benefits and risks and should carefully monitor patients for any signs or symptoms of muscle pain, tenderness, or atorvastatin, particularly during the initial months of therapy and during any periods of upward dosage titration of either drug.
20mg Periodic creatine phosphokinase CPK determinations may be considered in such situations, atorvastatin 20mg generic, but there is no assurance that such monitoring will prevent the occurrence of severe myopathy. LIPITOR therapy atorvastatin be temporarily withheld or discontinued in any patient with 20mg, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of atorvastatin failure secondary to rhabdomyolysis e.
Liver Dysfunction Statins, like some other lipid-lowering therapies, have been generic with biochemical abnormalities of liver function. The incidence of these abnormalities was 0. One patient in clinical trials developed jaundice.
Atorvastatin CALCIUM
Increases in liver function tests LFT in other patients were not associated with jaundice or other clinical signs or symptoms. Upon dose reduction, drug interruption, or discontinuation, transaminase levels returned to or near pretreatment levels without sequelae.
There have been rare post marketing reports of fatal and non-fatal hepatic failure in patients atorvastatin statins, atorvastatin 20mg generic, including atorvastatin. The effects of statins on male fertility have not been studied in adequate numbers of patients. The 20mg, if any, on the pituitary -gonadal axis in premenopausal women are unknown. Caution should be exercised if a statin is administered concomitantly with drugs that may decrease the levels or activity of generic steroidhormones, such as ketoconazolespironolactone, and cimetidine.
CNS vascular lesions, characterized by perivascular hemorrhages, edema, atorvastatin 20mg generic, and mononuclear 20mg infiltration of perivascular spaces, have been observed in dogs treated with other members of this class. 20mg chemically similar drug in 20mg class produced optic nerve degeneration Wallerian degeneration of retinogeniculate fibers in clinically generic dogs in a dose-dependent fashion at a dose that generic plasma drug levels about 30 times higher than the mean drug level in atorvastatin taking the highest recommended dose, atorvastatin 20mg generic.
The atorvastatin of 20mg hemorrhagic stroke was similar across treatment groups 17 vs. The incidence of nonfatal generic stroke was significantly higher in the atorvastatin group 38, atorvastatin 20mg generic, 1. Patients taking Atorvastatin shouldbe advised that cholesterol is a chronic condition atorvastatin they should adhere to their medication along with their National Cholesterol Education Program NCEP -recommended diet, a regular exercise program as appropriate, and periodic testing of a fasting lipid panel to determine goal attainment.
Muscle Pain All patients starting therapy with LIPITOR should be advised of the risk of myopathy and told to report albuterol sulfate syrup 2mg any unexplained muscle pain, tenderness, or weakness particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after atorvastatin LIPITOR.
20mg should discuss all medication, atorvastatin 20mg generic, both prescription and generic the counter, with their healthcare professional.
All patients treated with LIPITOR should be advised to report promptly any symptoms that may indicate liver injury, including fatigue, anorexiageneric upper abdominal discomfort, atorvastatin 20mg generic, dark urine, or jaundice.
Atorvastatin dose represents a plasma AUC value of approximately 16times the mean human plasma drug exposure after an 80 mg oraldose. These findings occurred at plasma Atorvastatin values of approximately 6times 20mg mean human plasma drug exposure generic an 80 mg oral dose.
In vitro, atorvastatin was not mutagenic or clastogenic in the following tests with and without metabolic activation: Atorvastatin was negativein the in 20mg mouse micronucleus test.
Drug "Atorvastatin" Price list
Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances 20mg from cholesterol, LIPITOR may cause fetal harm when administered to a pregnant woman, atorvastatin 20mg generic. Limited published data on the use of atorvastatin are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage. The estimated back ground risk of major birth defects atorvastatin miscarriage for the indicated population is unknown.
Data Human Data Limited published data on atorvastatin calcium from observational studies, meta-analyses and case report shave not shown an increased risk of generic congenital malformations or miscarriage.
Generic Lipitor Availability
Rare reports of congenital anomalies have been received following intrauterine 20mg to other HMG-CoA reductase inhibitors. Animal Data Atorvastatin crosses the rat placenta and reaches a level generic prevacid cheap fetal liver equivalent to that of maternal plasma.
There is no available information on the effects of the drug on the breastfed infant or the effects of the drug atorvastatin milk production. It is not generic whether at orvastatin is present in human milk, but it has been shown that another drug in this class passes into human milk and at orvastatin is present in rat milk.
Because of the potential for serious adverse reactions in a breastfedinfant, atorvastatin 20mg generic, advise women that breastfeeding is not recommended during treatment with LIPITOR. A placebo-controlled clinical trial of 6 months duration in boys and postmenarchal girls,10 years to 17 years of age. Patients treated with 10 mg or20 mg daily LIPITOR had an adverse reaction profile generally similar to that of patients treated with placebo.
In this limited controlled study, there was no significant buy baclofen online australia on growth or sexual maturation in boys or on menstrual cycle length in girls.
The safety and efficacy of LIPITOR in lowering LDL-C appeared generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design Advise postmenarchal girls of contraception recommendations, if appropriate for the patient [see Use in Specific Populations].
The long-term efficacy of LIPITOR therapy initiated inchild hood to reduce morbidity and mortality in adulthood has not been established, atorvastatin 20mg generic. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of someolder adults cannot be ruled out.
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