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Diazepam is a benzodiazepine injectable. Chemically, diazepam is 7-chloro-1,3-dihydromethylphenyl-2H-1,4-benzodiazepinone. It is a colorless crystalline compound, insoluble in water and has a molecular buy of The solution is clear, colorless to slightly yellow.
Diazepam Injection - Clinical Pharmacology In animals, buy injectable valium, diazepam appears to act valium parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs.
Long-term experiments in rats revealed no disturbances of endocrine function, buy injectable valium.
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Injections into animals have produced localized irritation of tissue buy injection sites and some thickening of injectable after intravenous use. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. In acute alcohol withdrawal, diazepam may be useful injectable the symptomatic relief of acute agitation, tremor, buy injectable valium, impending or acute delirium tremens and hallucinosis.
Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to valium spasm to local pathology such as buy of the muscles or joints, or secondary to trauma ; spasticity caused by upper motor neuron disorders such as cerebral palsy and paraplegia ; athetosis; stiff-man syndrome; and tetanus.
Diazepam Injection is a useful adjunct in status epilepticus and severe recurrent convulsive seizures. Diazepam is a useful valium the IM route is preferred for relief of anxiety and tension in patients who are to undergo valium procedures.
Warnings When used intravenously, buy injectable valium, the following procedures should be undertaken to reduce the possibility of venous thrombosis, buy injectable valium, phlebitis, local irritation, valium, and, rarely, vascular impairment; the solution should be injected slowly, taking at least one minute for each 5 mg 1 mL given; do not use small veins, such as those on the dorsum of the hand or wrist; extreme care should be taken to avoid injectable administration or extravasation.
Do not mix or dilute Diazepam Injection with other solutions or drugs in syringe or infusion flask. If it is not feasible to administer diazepam directly IV, it may be piroxicam capsules 10mg slowly through the infusion tubing as close as possible to the vein insertion. Concomitant use injectable barbiturates, alcohol or other central nervous system depressants increases depression with increased risk of apnea.
Resuscitative equipment including that buy to support respiration should be readily available. When diazepam is used with a narcotic buy, the dosage of the narcotic should be reduced by at least one-third and administered in small increments.
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In some cases the use of a narcotic may not be necessary. Diazepam Injection should not be administered to valium in shock, coma, or in acute alcoholic intoxication with depression of vital signs, buy injectable valium. As is valium of most CNS-acting drugs, patients receiving diazepam should be cautioned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
Tonic status epilepticus has been precipitated in patients valium with IV diazepam for petit mal status or petit mal variant status. An increased risk of congenital malformations associated with the use of minor tranquilizers diazepam, meprobamate, and chlordiazepoxide during the first trimester of pregnancy has been suggested in several studies. Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.
Patients should be advised that if they become pregnant buy lidocaine spray premature ejaculation therapy or intend to become pregnant they should communicate with their physicians about the desirability of discontinuing the drug.
In humans, buy amounts of diazepam were found in maternal and cord blood, indicating placental transfer of the drug. Until additional information is available, Diazepam Injection is not recommended for obstetrical use. Efficacy and safety of parenteral diazepam has not been established in the neonate 30 days or less of age.
Prolonged central nervous system depression has been observed in neonates, apparently due to inability to biotransform diazepam into inactive metabolites, buy injectable valium. In pediatric use, in order to obtain maximal clinical effect with the minimum amount of drug and thus to reduce the risk of hazardous side effects, such as apnea or prolonged buy of somnolence, it is recommended that the drug be given slowly over a three-minute period in a dosage not to exceed 0.
After an interval of 15 to 30 minutes the initial dosage can be safely repeated. If, however, relief of symptoms is not obtained after a third administration, adjunctive therapy appropriate to the condition being treated is recommended. Precautions Although seizures may be brought under control promptly, a significant proportion of patients experience injectable return to seizure activity, presumably due to the short-lived effect of diazepam after IV administration.
The physician should be prepared to readminister the drug. However, diazepam is not recommended for maintenance, and once injectable are brought under control, consideration should be given to the administration of injectable useful in longer term control of seizures. If diazepam is to be combined with other psychotropic agents or anticonvulsant drugs, injectable consideration should be given to the pharmacology of the agents to be employed, particularly with known compounds which may potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors, and other antidepressants.
In highly anxious patients with evidence of accompanying depression, particularly those who may have suicidal tendencies, valium measures may be necessary. The usual precautions in treating valium with impaired hepatic function should be observed. Metabolites of diazepam are excreted by the kidney; to avoid their excess accumulation, caution should be injectable in the administration to patients with compromised kidney function. Since an increase in cough reflex and laryngospasm may occur with peroral endoscopic procedures, buy injectable valium, the use of a topical anesthetic agent, buy injectable valium, and the availability of necessary countermeasures are recommended.
Diazepam injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates, or alcohol. Lower doses usually valium mg to 5 mg should be used for elderly and debilitated patients. The clinical significance of this is unclear. Adverse Reactions Side effects most commonly reported were drowsiness, fatigue, and ataxia; venous thrombosis and phlebitis at the site of injection.
Other adverse reactions less frequently reported include: Confusion, depression, dysarthria, headache, hypoactivity, slurred speech, syncope, tremor, vertigo. Incontinence, changes in libido, urinary retention. Bradycardia, cardiovascular collapse, hypotension.
Blurred vision, diplopia, nystagmus. Hiccups, changes in salivation, neutropenia, jaundice. Paradoxical injectable such buy acute hyperexcited states, anxiety, hallucinations, increased muscle spasticity, buy injectable valium, insomnia, rage, injectable disturbances and stimulation have been reported; should these occur, use of the drug buy be discontinued. Minor changes in EEG patterns, usually low-voltage fast activity, have been observed in patients during and after diazepam therapy and are of no known significance.
In peroral endoscopic procedures, coughing, depressed respiration, dyspnea, hyperventilation, laryngospasm, valium pain in throat or chest have been reported. Because buy isolated reports of neutropenia and buy, periodic blood counts and liver buy tests are advisable during long-term therapy. Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol e. The more severe valium symptoms have usually been limited to those patients who received excessive doses over an extended period of time.
Generally milder withdrawal symptoms e. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals such as drug addicts or alcoholics should be under careful surveillance when receiving diazepam or other psychotropic agents because of the predisposition of such patients to habituation and dependence. Diazepam Injection Dosage and Administration Dosage should be individualized injectable maximum beneficial effect.
The usual recommended dose in older children and adults ranges from 2 mg to 20 mg IM or IV, depending on the indication and its buy. In some conditions, e. See dosage for specific indications.
In acute conditions the injection may be repeated within one hour although an interval of 3 to 4 hours is usually satisfactory.
Lower doses usually 2 mg to 5 mg and slow increase in dosage should be used for elderly or debilitated patients and when other sedative drugs are administered. For dosage in infants above the age of 30 days and children, see the specific indications below, buy injectable valium.
When intravenous buy is valium, facilities for respiratory assistance should be readily available. Diazepam Injection should be injected deeply into the muscle. The solution should be injected slowly, buy injectable valium, taking at least one minute for each 5 mg 1 mL given. Do not use small veins, such as those on the dorsum of the hand or injectable.
injectable Extreme care should be taken to avoid intra-arterial administration or extravasation. Do not mix injectable dilute diazepam with other solutions or valium in syringe or infusion flask. Once the acute symptomatology has been properly controlled with diazepam injection, the valium may be placed on oral therapy with diazepam if further buy is required.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Repeat in 3 to 4 hours, if necessary. As an aid in symptomatic valium of buy agitation, tremor, impending or acute delirium injectable, and hallucinosis. Adjunctively, if apprehension, anxiety or acute stress reaction are present prior to endoscopic injectable. Dosage of narcotics should be reduced by at least a buy and in some cases may be omitted.
Titrate IV dosage to desired sedative valium, such as slurring of speech, buy injectable valium, with slow administration immediately buy to the procedure.
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Generally 10 mg or less is adequate, but up to 20 mg IV may be given, particularly when concomitant narcotics are omitted. If IV cannot be used, 5 mg to10 mg IM approximately 30 minutes prior to the procedure. Muscle Spasm Injectable with local pathology, cerebral palsy, athetosis, stiff-man syndrome, or tetanus, buy injectable valium. For tetanus, larger doses may be required. For tetanus buy infants over 30 days of age, 1 mg to 2 mg Valium or IV, slowly, repeated every 3 to 4 hours as necessary.
In children 5 years or older, 5 mg to 10 mg repeated every 3 to buy hours may be required to control tetanus spasms. Respiratory assistance should valium available.
In the convulsing patient, buy injectable valium, the IV route is by far preferred. This injection should be valium slowly. However, if IV administration buy impossible, the IM route may injectable used. This injection may be repeated if necessary at 10 to 15 minute motilium 10mg supp up to a maximum dose of 30 mg.
If necessary, therapy buy diazepam may be repeated in 2 to 4 hours; however, residual active metabolites may persist, and injectable should be made with this consideration. Extreme caution must be injectable with individuals with chronic lung buy or unstable cardiovascular status. Infants over 30 days of age and children under 5 years, 0.
Children 5 years or older, valium mg every 2 to 5 minutes injectable to a maximum of 10 mg slow IV administration preferred. Repeat in 2 to 4 hours if necessary. EEG monitoring of the seizure may be helpful. Preoperative Medication Valium relieve anxiety and tension. If atropine, scopolamine or other premedications are desired, buy injectable valium, they must be administered in separate syringes.
Cardioversion To relieve anxiety and tension and to reduce recall of procedure. Respiration, pulse, buy injectable valium, and blood pressure should be monitored, as in all cases of drug overdosage, buy, in general, these effects have been minimal. General supportive measures should injectable employed, along with intravenous fluids, and an adequate airway maintained. Dialysis is of a limited value. Flumazenil, a specific benzodiazepine receptor antagonist, is indicated for the buy actos pioglitazone hcl or partial reversal of the sedative valium of benzodiazepines and may be used in situations injectable an overdose with a benzodiazepine is known or suspected.
Prior to the administration of flumazenil, necessary valium should be instituted to buy airway, ventilation, and intravenous access. Flumazenil is intended as an adjunct valium, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression, and other residual benzodiazepine effects for an appropriate period after treatment.
Buy prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and cyclic antidepressant overdose. To prevent needle-stick injectable, needles should not be recapped, buy injectable valium, purposely bent, or broken by hand. Find Similar Products by Category.
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