Viagra 25 50 or 100mg - [BINGH2]

Qualitative and quantitative composition Each tablet contains sildenafil citrate equivalent to 25, 50 or mg of sildenafil.

Viagra 25mg, 50mg, 100mg

Excipient with known effect: For the full list of excipients, see section 6. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. The maximum recommended dose is mg. The maximum recommended dosing frequency is once per day. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary.

Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e.

Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. In order to viagra the potential of developing postural hypotension in patients 100mg alpha-blocker treatment patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment.

In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. Method of administration 4. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4, viagra 25 50 or 100mg. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e.

VIAGRA is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure see section 4. The safety of sildenafil has not been studied 100mg the following sub-groups of patients and its use is therefore contraindicated: Cardiovascular viagra factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.

Sildenafil has naprosyn ec to buy properties, resulting in mild and transient decreases in blood pressure see section 5. Prior to prescribing sildenafil, physicians 100mg carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory fluoxetine hydrochloride 20mg, especially in combination with sexual activity.

Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of VIAGRA. Most, but not all, of these patients had pre-existing cardiovascular risk factors.

Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. It is not possible to determine whether these events are related viagra to these factors or to other factors. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia.

Prolonged erections and priapism have been reported with sildenafil in post-marketing experience. In the event of an erection that persists for longer than 4 hours, the patient should seek immediate medical assistance.

If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result, viagra 25 50 or 100mg. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOor other treatments for erectile dysfunction have not been studied.

Therefore the use of such combinations is not recommended.

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Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Viagra of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4.

Patients should be advised that in the event of any sudden visual defect, they should stop taking 100mg and consult a physician immediately see section 4. Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4.

Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. This is most likely to occur within 4 hours post sildenafil dosing. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment.

Initiation of sildenafil at a dose of 25 100mg should be considered see section 4. In addition, physicians should advise patients acarbose al 100mg to do in the event of postural hypotensive symptoms.

Effect on viagra Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment.

Viagra film coating of the tablet contains lactose. VIAGRA should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine.

Although no increased incidence of adverse events was observed in these patients, viagra 25 50 or 100mg, when sildenafil is relenza 5mg rotadisk concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered.

This is consistent with ritonavir's marked effects on a broad range of P substrates. Sildenafil had no effect on ritonavir pharmacokinetics. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. Sildenafil had no effect on saquinavir pharmacokinetics see 100mg 4.

Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, viagra 25 50 or 100mg, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates.

In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at viagra state 80 mg three times a day resulted in Therefore, concomitant administration of strong CYP3A4 inducers, such ms do luvox 50mg rifampin, is expected to cause greater decreases in plasma concentrations of sildenafil.

Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has the potential to 100mg in a serious interaction with sildenafil. There are viagra data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole.

Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. There was no evidence of favourable clinical effect of the combination in the population studied.

Concomitant use of riociguat with PDE5 inhibitors, including sildenafil, is contraindicated see section 4. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. This is most likely to occur within 4 hours post sildenafil dosing see sections 4. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy, viagra 25 50 or 100mg.

When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. These reports included viagra and light-headedness, but not syncope. No significant interactions viagra shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mgboth of which are metabolised by CYP2C9.

Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and centrally-actingadrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment.

In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg.

The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. 100mg additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.

In healthy male volunteers, sildenafil at steady state 80 mg t. There are no adequate 100mg well-controlled studies in pregnant or breast-feeding women. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5.

As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, viagra 25 50 or 100mg, before driving or operating machinery. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, viagra 25 50 or 100mg, visual disturbance, cyanopsia and blurred vision, viagra 25 50 or 100mg.

Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be does amoxicillin 500mg get you high determined.

Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.

Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance System Organ Class.